A disseminated Mycobacterium marinum infection in a renal transplant HIV-infected patient successfully treated with a bedaquiline-containing antimycobacterial treatment: A case report
نویسندگان
چکیده
Abstract Background Disseminated Mycobacterium marinum infections occur rarely, in immunocompromised patients. Treatment with a prolonged multi-drug regimen exposes patients to drug–drug interactions and side effects. Case report We case of disseminated M. infection 54-year-old renal transplant, HIV-infected woman. Manifestations the were cutaneous subcutaneous nodules, mediastinal lymph nodes left pulmonary infiltrate. Empirical treatment for non-tuberculous mycobacteria was initiated rifabutin, ethambutol azithromycin. After identifying sputum, due unfavourable clinical evolution severe drug-related adverse events, changed doxycycline rifabutin. Digestive haematologic effects motivated change antimycobacterial combination moxifloxacin bedaquiline. Tolerance satisfactory, patient cured after 12 months treatment. Conclusion (to authors’ knowledge) first successfully treated bedaquiline-containing regimen. Bedaquiline could be an alternative recommended antimicrobial regimens cases mycobacterial disease, including infection.
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2021
ISSN: ['1878-3511', '1201-9712']
DOI: https://doi.org/10.1016/j.ijid.2021.04.054